Figure 3.

Phylogeny and sequence divergence of Orthohepevirus species. (A) Phylogenetic relationships of Orthohepevirus species. A conserved region of the capsid protein (nucleotide positions 5485–6497, numbered according to M73218) was aligned for representative isolates and the amino acid sequence used to generate a maximum likelihood tree based on the LG model with a γ distribution of evolutionary rates among sites as implemented in the program MEGA6 (Tamura et al. 2013). Branches supported in >70% of bootstrap replicates are indicated. Genotypes, virus species, and host species are indicated. (B) Scan of amino acid diversity across the Orthohepevirus genome. The sequences used to produce Figure 3A were analyzed as described in Figure 1B.