Table 2.
AUCs and 95% CIs of Stepwise Selected Biomarker Models Using 5-fold Cross-validation
| Model details | Predictors | AUC (95% CI) | AUC (95% CI) with risk factors for BE |
|---|---|---|---|
| Risk factors for BE | Age, sex, ethnicity, smoking, body mass index, waist-hip ratio | 0.71 (0.64–0.77) | — |
| All miRNAs that univariately positively predicted BE in Cytosponge application | MIR7, 10a, 30a, 145, 181a, 192, 194, 196a, 199a, 199b, 215 | 0.87 (0.82–0.92) | 0.84 (0.79–0.89) |
| Stepwise selection of miRNAs from initial model | MIR7, 30a, 181a, 192, 196a, 199a | 0.89 (0.84–0.93) | 0.88 (0.83–0.93) |
| Above model plus TFF3 | MIR7, 30a, 181a, 192, 196a, 199a plus TFF3 | 0.92 (0.88–0.96) | 0.92 (0.88–0.96)a |
| Stepwise selection of miRNAs from initial model and TFF3 (3 miRNAs and TFF3) | MIR192, 196a, 199a, plus TFF3 | 0.93 (0.90–0.97) | 0.91 (0.87–0.95) |
a
Model did not include smoking due to failure to converge.