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. 2018 Feb 28;57(15):2105–2114. doi: 10.2169/internalmedicine.9842-17

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Copyright © 2018 by The Japanese Society of Internal Medicine

The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure 4. — Renal outcomes in the integrated CANVAS program (modified from 6). A: Kaplan-Meier analysis of progression of albuminuria. B: Kaplan-Meier analysis of a renal composite outcome (40% reduction in eGFR, requirement for renal-replacement therapy, or death from renal causes). The inset shows the data on an expanded y axis. eGFR: estimated glomerular filtration rate

Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377: 644-657, 2017.