Fig. 6.

Nonlinear outward rectification of GABARs effectively counterbalances NMDAR activation in a dendritic branch model. a Family of voltage traces of burst activation of an increasing number of glutamatergic inputs (1, 3, 5, and 7; 0.14 nS each) in the presence of one GABAergic SOM-like model synapse that exhibits nonlinear outward rectification as observed experimentally (Supplementary Fig. 4; 0.28 nS at rest, 0.7 nS max). b Responses to the same stimulation when the GABAR conductance did not show a voltage-dependent increase and was constant (0.28 nS). c Responses when only the outward-rectifying conductance of the GABAR was active (0.14 nS at rest, 0.56 nS max). d Responses when the outward-rectifying conductance of the GABARs was reduced by 50% (0.21 nS at rest, 0.42 nS max). e The dependence of the peak burst amplitude on glutamatergic input number. Note the near-linear increase of the burst amplitude for nonlinear inhibition and the strongly nonlinear behavior for reduced or removed outward rectification of inhibition. f Dependence of the peak burst amplitude on input number when only AMPARs were present in the glutamate synapses