Fig. 7.

Slow kinetics of outward-rectifying GABARs allow for effective inhibition of NMDAR-mediated electrogenesis. a Family of voltage traces of burst activation of an increasing number of glutamatergic inputs (1, 3, 5, 7, and 9; 0.14 nS each) in the presence of one nonlinear SOM-like GABAergic model synapse with slow kinetics. b Responses to the same stimulation when the nonlinear GABAergic model synapse has five-times faster kinetics (rise τ = 0.2 ms; decay τ = 6 ms) similar to PV-basket-cell-mediated perisomatic inhibition. c The amplitude of the conductance was additionally scaled by a factor of 5 (from 0.7 to 3.5 nS) to compensate for the decreased inhibitory charge when kinetics are faster. Note that despite the same total integral conductance, fast scaled inhibition was less effective at preventing NMDAR-mediated dendritic spikes. d–f The same simulations when only AMPARs were present in glutamate synapses. Note the larger effect of fast scaled inhibition onto AMPAR-mediated depolarization. g Pure AMPAR responses without any inhibition. h The dependence of the peak burst amplitude on glutamatergic input number. Note the strongly nonlinear behavior for both forms of fast inhibition. i Dependence of the peak burst amplitude on input number when only AMPARs were present in the glutamate synapses