Skip to main content
. 2018 Sep 3;9:3562. doi: 10.1038/s41467-018-05807-z

Table 1.

The hotspot genes in non-mutator and mutator strains

Non-mutator strains Mutator strains
Gene Function Frequency P value Gene Function Frequency P value
rpoB RNA polymerase sigma 24 29.8% −99 gyrB DNA gyrase 52.9% −22
pykF Pyruvate kinase I 20.2% −85 rpoB RNA polymerase sigma 24 41.2% −18
rph RNase PH 15.5% −47 chiA Endochitinase 41.2% −19
malT MalT-maltotriose-ATP DNA-binding transcriptional activator 14.8% −42 rpoC RNA polymerase sigma 24 35.3% −14
ybaL Putative transport protein, monovalent cation: proton antiporter-2 (CPA2) family 14.3% −38 bcsZ Endo-1,4-d-glucanase 35.3% −15
rbsK Ribokinase 14.3% −40 adhE Aldehyde alcohol dehydrogenase 35.3% −13
rbsA Ribose ABC transporter 14.3% −41 mreC Membrane protein required for maintenance of rod shape 29.4% −12
spoT Guanosine 3r- diphosphate 5r- triphosphate 3r-diphosphatase 13.7% −26 secA Protein translocation ATPase 29.4% −13
topA DNA topoisomerase I 13.1% −35 ycaL Predicted peptidase with chaperone function 29.4% −11
nadR NadR DNA-binding transcriptional repressor and NMN adenylyl transferase 13.1% −36 eptB Kdo2-lipid A phospho-ethanolamine7-transferase 29.4% −10
rbsD Ribose pyranase 13.1% −38 elfC Predicted outer membrane usher protein 29.4% −10
rbsB Ribose ABC transporter 13.1% −39 fepE Obactin (enterochelin) transport 29.4% −11
rbsR RbsR-ribose 13.1% −36 ravA Regulatory 29.4% −9
fis Fis DNA-binding transcriptional dual regulator 13.1% −32 yeaH Conserved protein 29.4% −11
hslU HslVU protease 12.5% −35 glnE Glutamine synthetase adenylyl transferase glutamine synthetase deadenylase 29.4% −12
envZ EnvZ sensory histidine kinase 12.5% −35 rhsC RhsC protein in rhs element 29.4% −9
hsrA Putative transport protein, major facilitator superfamily (MFS) 11.9% −30 ybjL Inner membrane protein YbjL 29.4% −8
metL Aspartate kinase/ homoserinede-hydrogenase 11.3% −27 ymfD e14 prophage; predicted SAM-dependent methyltransferase 29.4% −11
mrdB Rod shape-determining membrane protein; sensitivity and drug 10.7% −30 yrfF Inner membrane protein inhibits the Rcs signaling pathway 29.4% −10
iclR IclR-glyox 10.1% −28 glyQ Glycyl-tRNA synthetase 29.4% −12

The p value is in log10 scale