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. 2018 Sep 3;8:13134. doi: 10.1038/s41598-018-31372-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Upkeeping of glycolysis, OXPHOS, and the PPP in EC cell necessitates SRC-2. (A) Extracellular acidification rate (ECAR), measured before and after the addition of glucose and after the additions of oligomycin and 2-deoxyglucose (2-DG); quantification of the areas under the curves (AUC) are presented in (B). (C) Measurement of oxygen consumption rate (OCR) under the same conditions as described in (A) with AUC quantified in (D). (E) Quantification of steady metabolite levels in Ishikawa cells after control and SRC-2 knockdown. Each column represents a biological replicate of cells after either control or SRC-2 siRNA transfection (numbers 1–4 indicate biological replicates). Each row represents quantification of a metabolite which has been normalized with R heatmap.2() function’s default z-score row scaling. (F) Levels of mRNAs encoding enzymes of the PPP measured by RT-qPCR.