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. 2018 Sep 3;8:13134. doi: 10.1038/s41598-018-31372-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RPIA maintains glycolytic capacity, oxidative phosphorylation, and the PPP. (A) Extracellular acidification rate (ECAR) with quantification of the areas under the curves (AUC) presented in (B) of cells transfected with control, SRC-2, or RPIA siRNA. (C) Measurement of the oxygen consumption rate (OCR) under the same conditions as described in (A) with AUC quantified in (D). (E) Proportion of ¹²C- and ¹³C-containing metabolites of glycolysis, the TCA cycle, and the PPP isolated from Ishikawa cells before and after a 3 h treatment with ¹³C(6)-glucose. The x axis labels indicate the metabolites containing only ¹²C (m + 0) or also ¹³C (m + 1, +2, +3, +4, +5, +6, and +7) isotopes.