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. 2018 Sep 3;8:13156. doi: 10.1038/s41598-018-31584-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of results. P/Q-type channels are modulated by CaMKII to generate gamma band oscillations (green structures). TSA blocked these oscillations and reduced I_Ca in PPN cells by inhibiting HDAC I and II (pink structures). KN-93 blunted the effects of TSA, suggesting that HDAC II action on CaMKII may be required for potential transcription following P/Q-type channel-mediated gamma oscillations. Inhibition of HDAC I by MS275, or of HDAC IIb by tubastatin A, in the nucleus had no effects on I_Ca or oscillations. However, MC1568 inhibition of HDAC IIa had the same effect as TSA in reducing I_Ca and oscillations. These effects were evident in cells with P/Q-type channels (N + P/Q and P/Q-only cells) but there were no effects on N-only cells that are modulated by cAMP/PKA (blue structures).