Table 1.
Clinical characteristics of patients with pulmonary tuberculosis.
| Tenryu Cohort (n = 96) | Shizuoka Cohort (n = 112) | p-value | |
|---|---|---|---|
| Sex, M/F | 62/34 | 71/41 | 0.886 |
| Age, yr | 72.4 ± 21.5* | 71.8 ± 19.6 | 0.410 |
| Body mass index | 19.1 ± 3.4 (n = 78) | 18.8 ± 3.4 (n = 110) | 0.347 |
| Mortality | 22 (22.9%) | 26 (23.2%) | 1.000 |
| Current smoker | 14 (14.6%) | 17 (15.2%) | 1.000 |
| System involved | |||
| Pulmonary tuberculosis only | 53 (55.2%) | 81 (72.3%) | 0.013 |
| Tuberculous pleurisy | 37 (38.9%) | 25 (22.3%) | 0.010 |
| Disseminated tuberculosis | 12 (12.5%) | 9 (8.0%) | 0.376 |
| Osteoarticular tuberculosis | 3 (3.1%) | 4 (3.6%) | 1.000 |
| Bronchial tuberculosis | 0 (0%) | 4 (3.6%) | 0.126 |
| Tuberculous colitis | 2 (2.1%) | 1 (0.9%) | 1.000 |
| Radiographic findings | |||
| Cavity | 26 (27.1%) | 63 (56.3%) | <0.001 |
| Microbiological findings | |||
| Suputum smear (0, 1+, 2+, 3+, 4+) | 8, 47, 15, 16, 10 | 2, 44, 21, 36, 9 | 0.024 |
| MDR-TB, no. (%) | 1 (1.0%) | 2 (1.8%) | 1.000 |
| Comorbidity, no. (%) | |||
| Congestive heart failure | 14 (14.6%) | 20 (17.9%) | 0.576 |
| Chronic pulmonary disease | 13 (13.5%) | 20 (17.9%) | 0.450 |
| Renal disease | 6 (6.3%) | 4 (3.6%) | 0.518 |
| Diabetes mellitus | 13 (13.5%) | 20 (17.9%) | 0.450 |
| Liver disease | 3 (3.1%) | 3 (2.7%) | 1.000 |
| Cerebrovascular disease | 22 (22.9%) | 20 (17.9%) | 0.390 |
| Neoplasm | 9 (9.4%) | 9 (8.0%) | 0.807 |
| Chronic corticosteroid treatment | 7 (7.3%) | 5 (4.4%) | 0.553 |
| Clinical characteristics on admission | |||
| Body temperature, °C | 36.9 ± 0.7 | 36.8 ± 0.9 | 0.509 |
| Heart rate, rate/min | 83.7 ± 15.5 | 86.0 ± 15.8 | 0.145 |
| Respiratory failure (SaO2 < 90%), no. (%) | 22 (10.6%) | 17 (8.2%) | 0.160 |
| Impaired consciousness, no. (%) | 5 (5.2%) | 4 (3.6%) | 0.736 |
| Laboratory findings | |||
| BUN, (8.6–21.6 mg/dl)** | 19.1 ± 13.1 | 17.6 ± 10.4 | 0.665 |
| TP, (6.7–8.1 g/dl) | 6.8 ± 1.0 | 7.1 ± 1.0 | 0.042 |
| Alb, (3.9–4.9 mg/dl) | 3.1 ± 0.8 | 3.0 ± 0.8 | 0.283 |
| Cre, (0.70–1.17 mg/dl) | 0.80 ± 0.45 | 0.81 ± 0.39 | 0.228 |
| WBC, (3600–9200/mm3) | 6986 ± 2867 | 7958 ± 3759 | 0.020 |
| ESR, (2–10 mm/H) | 64.7 ± 33.7 (n = 84) | 44.5 ± 29.8 (n = 111) | <0.001 |
| CRP, (≦0.10 mg/dl) | 5.2 ± 4.7 | 5.7 ± 6.1 | 0.914 |
| SAA, (≦10 μg/ml) | 380 ± 401 (n = 84) | 408 ± 610 (n = 111) | 0.474 |
MDR-TB, multidrug resistant tuberculosis; SaO2, arterial oxygen saturation; BUN. blood urea nitrogen; TP, total protein; Alb, alubumin; Cre, creatinine; WBC, white blood cell count; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; SAA, serum amyloid A; PCT, procalcitonin. *Mean ± SD; **Normal range.