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. 2018 Aug 28;6:98. doi: 10.3389/fcell.2018.00098

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Copyright © 2018 Haro and Orsulic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CAFs have an inverse association with tumor stage in DLBCL and ovarian carcinoma. Enrichment of the DLBCL stromal-1 gene signature in progression stages I-IV in (A) three DLBCL microarray datasets (GSE10846, GSE87371, and GSE4475) that were combined into one dataset, and (B) The Cancer Genome Atlas (TCGA) ovarian carcinoma dataset (https://cancergenome.nih.gov). The gene signature enrichment analysis was performed using the R2 Genomics Analysis and Visualization Platform (https://hgserver1.amc.nl). The y axis shows relative enrichment of the DLBCL stomal-1 gene signature. The x axis shows tumor stage. The number of samples for each tumor stage is indicated in parentheses.