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. 2018 Aug 28;8:324. doi: 10.3389/fonc.2018.00324

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Copyright © 2018 Bisetto, Whitaker-Menezes, Wilski, Tuluc, Curry, Zhan, Snyder, Martinez-Outschoorn and Philp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCT4 is expressed in Human OSCC: Single MCT4 (A,B) and dual MCT4/CD163 (C–E) immunostaining in paraffin embedded samples of human OSCC. Area of adjacent normal epithelium in OSCC sample #1 (A), area of squamous cell carcinoma within the same sample #1 (B). MCT4 negative/CD163 positive macrophages in adjacent normal area of oral mucosa in sample #2 (C). MCT4 positive/CD163 positive macrophages in areas of cancer cells within same sample #2 (D). Boxed region in D is showed at higher magnification in E (2.5X). Scale bar: 20 μm. S, stroma; E, epithelium.