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. 2018 Aug 28;8:324. doi: 10.3389/fonc.2018.00324

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Copyright © 2018 Bisetto, Whitaker-Menezes, Wilski, Tuluc, Curry, Zhan, Snyder, Martinez-Outschoorn and Philp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of peri-lesional macrophages in wild type and MCT4^−/− tumors. Immunofluorescence staining for F4/80 (green) and MCT4 (red) and dapi nuclear staining (blue) in wild type and MCT4^−/− tongue frozen sections at 23 weeks of 4NQO treatment (A–F) scale bar: 20μm. F4/80 staining of frozen sections in untreated tongues and at 14 and 23 weeks 4NQO treatment in wild type and MCT4^−/− animals (G–L) Scale bar: 20 μm. Quantification of F4/80 positive macrophages in tongue sections. Involved areas represent regions identified by nuclear atypia and/or other signs of epithelial transformation, whereas non-involved areas did not display these features within the same section (n = 3 for untreated, n = 8 for 14 weeks, n = 4 for 23 weeks per group) (M). Quantification of total monocytes (N) in peripheral blood (n = 5–6 per group). *P < 0.05.