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. 2018 Aug 28;9:1965. doi: 10.3389/fimmu.2018.01965

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Copyright © 2018 Pang, Song, Lu, Zhang, Zheng, Jiang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HIV-1_NL4−R3A and stHIV-1sv replicated more robustly than HIV-1_NL4.3 in PBMCs of northern pig-tailed macaques. (A) The genomic structures of HIV-1_NL4−R3A, and stHIV-1sv in comparison to that of HIV-1_NL4−3. (B) Replication of HIV-1_NL4−3, HIV-1_NL4−R3A and stHIV-1sv in PBMCs of NPMs. 1 × 10⁵ PBMCs from 2 healthy donors of NPMs were infected with these 3 viruses at an MOI of 0.01, replication was monitored by determining P24 concentration in supernatant at 3-day intervals post-infection.