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. 2018 Aug 28;9:1965. doi: 10.3389/fimmu.2018.01965

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Copyright © 2018 Pang, Song, Lu, Zhang, Zheng, Jiang and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antibody and Cotoxic lymphocyte(CTL) responses to the primary infection of northern pig-tailed macaques with HIV-1_NL4−R3A and stHIV-1sv. (A) Antibody responses to HIV-1_NL4−R3A and stHIV-1sv infection in NPMs were detected by western blotting analysis, the plasma at 4, 8, and 12 weeks postinfection (wpi) were used. (B) HIV-1 special neutralizing antibodies against these two viruses were measured respectively at 4, 12, 18 wpi. The inactivated plasma mixed with corresponding virus was added into Tzm-bl and the 50% reductions of virus infectivity (IC50) were calculated. (C) Cotoxic lymphocyte (CTL) responses to these two viruses were determined at 4 and 7 wpi. P-values were calculated by t-test.