Figure 6.

APOBEC3-induced HIV-1 hypermutation may contribute to the inhibition of virus replication during primary infection. Samples from HIV-1_NL4−R3A and stHIV-1sv infected 4 NPMs, respectively. The weeks post-infection were showed at the right side. Number in the table displayed the amount of hypermutation. There were more mutations caused by APOBEC3 family in HIV-1_NL4−R3A infected macaques than stHIV-1sv. The colors represented as: Red tick mark, GG>AG mutation (APOBEC3G pattern); Cyan tick mark, GA>AA mutation (APOBEC3F pattern); Green tick mark, GC>AC mutation; Magenta tick mark, GT>AT mutation; all other mutations; Yellow tick mark, deletion.