Table 3.
Potential urinary biomarkers of SXT treated type 2 diabetes rats.
| tR min | m/z | HMDB ID | VIP | Metabolite | Trenda | KEGG pathway |
|---|---|---|---|---|---|---|
| 4.34 | 302.3177 | 00269 | 1.78 | Sphinganine | ↑ | Sphingolipid metabolism |
| 3.00 | 162.0587 | 03320 | 4.07 | Indole-3-carboxylic acid | ↑ | Amino acids metabolism |
| 9.61 | 227.1862 | 00033 | 1.13 | Carnosine | ↓ | Histidine metabolism |
| 9.45 | 219.1748 | 01238 | 3.14 | N-Acetylserotonin | ↑ | Tryptophan metabolism |
| 1.03 | 229.1561 | 00806 | 2.08 | Myristic acid | ↑ | Fatty acid biosynthesis |
| 2.26 | 135.0627 | 00156 | 1.62 | L-Malic acid | ↓ | Pyruvate metabolism,TCA cycle |
| 4.39 | 130.0573 | 01369 | 1.38 | Pyrroline hydroxycarboxylic acid | ↑ | Arginine and proline metabolism |
| 1.41 | 120.0829 | 04041 | 1.43 | L-Allothreonine | ↑ | Glycine, serine and threonine metabolism |
| 2.04 | 206.0295 | 04096 | 2.02 | 5-Methoxyindoleacetate | ↓ | Tryptophan metabolism |
| 9.53 | 149.0436 | 01553 | 1.61 | 2-Oxo-4-methylthiobutanoic acid | ↓ | Cysteine and methionine metabolism |
| 6.09 | 297.0975 | 10350 | 6.81 | 2-Phenylethanol glucuronide | ↑ | Pentose and glucuronate interconversions, Starch and sucrose metabolism |
| 3.36 | 242.0066 | 00089 | 6.75 | Cytidine | ↑ | Pyrimidine metabolism |
| 7.51 | 199.1030 | 00638 | 2.52 | Dodecanoic acid | ↑ | Fatty acid biosynthesis |
| 3.47 | 134.0604 | 10715 | 5.78 | 2-Phenylacetamide | ↑ | Phenylalanine metabolism |
| 4.35 | 283.0675 | 00299 | 13.67 | Xanthosine | ↑ | Purine metabolism |
| 7.60 | 357.0754 | 01416 | 3.56 | Pantetheine 4′-phosphate | ↓ | Pantothenate and CoA biosynthesis |
| 3.51 | 255.0845 | 06809 | 3.47 | Nicotinate D-ribonucleoside | ↑ | Nicotinate and nicotinamide metabolism |
| 3.00 | 178.0462 | 00714 | 8.01 | Hippuric acid | ↓ | Phenylalanine metabolism |
Trenda Models vs. Controls: ↑ indicated increase; ↓ indicated decrease.