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. 2018 Aug 28;11:288. doi: 10.3389/fnmol.2018.00288

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Copyright © 2018 Liguori, Nuzziello, Introna, Consiglio, Licciulli, D’Errico, Scarafino, Distaso and Simone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combined molecular analysis in sALS. Functional annotations of experimentally validated target genes together with their miRNAs are visualized as a network (Cytoscape 3.6.0). Each node size is proportional to the degree of the node (connectivity). Green nodes correspond to functional annotations obtained by functional enrichment analysis (DAVID tool). Color gradient intensity of miRNA and target nodes correlates with upregulated (blue) or downregulated (red) expression levels.