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ER stress triggers autophagy after SCI. (A) 4-PBA and 3-MA were applied to specifically inhibit ER stress and autophagy. Representative western blots of GRP78, PDI, Beclin1, and LC3B I/II are shown. (B–E) Quantification of the expression of GRP78, PDI, Beclin1, and LC3B I/II. The relative band density value was normalized to that of GAPDH. All data are presented as the mean ± SEM, n = 5. ∗∗P < 0.01 versus the sham group, #P < 0.05 and ##P < 0.01 versus the SCI group.
