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. 2018 May 29;6(3):370–388.e3. doi: 10.1016/j.jcmgh.2018.05.008

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Impact of repeated V/M treatment on the microbial ecosystem in IL10^-/-mice. (A) Long-term experimental setup: IL10^-/- mice were left untreated or underwent repeated V/M treatment (2 times for 7 days at the age of 4 and 8 weeks) ± oral gavage of the serine protease inhibitor AEBSF (V/M-AEBSF) from 1 day before the beginning of the respective V/M treatment to Day 7. (B) Kinetic of the fecal microbiota composition in untreated versus V/M-treated IL10^-/- mice (family level). (C) MetaNMDS plot showing fecal microbiota profiles (beta diversity) of untreated versus V/M-treated IL10^-/- mice. (D) Microbial richness in ctr and V/M IL10^-/- mice. Color code: purple = during V/M treatment, light red = post V/M treatment (after first and second V/M treatments). (E) Relative abundance of Bacteroidaceae, Prevotellaceae, and Porphyromonadaceae in untreated versus V/M-treated IL10^-/- mice. The number of mice, in which the respective bacterial family was detected (prevalence) is depicted above the respective figure.