Table 2.
Findings of univariate and multivariate regression analyses of suspected risk factors for high on-treatment platelet reactivity after the administration of clopidogrel 300 mg in the acute phase of ischaemic stroke or a transient ischaemic attack.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Risk factor | OR (95% CI) | p-value | OR (95% CI) | p-value |
| Age | 1.04 (1.01–1.07) | <0.01 | 1.03 (0.995–1.06) | 0.10 |
| Female sex | 1.33 (0.74–2.40) | 0.35 | 1.11 (0.54–2.27) | 0.78 |
| Diabetes mellitus | 2.79 (1.14–6.82) | 0.03 | 1.74 (0.59–5.11) | 0.31 |
| PPI treatment | 2.50 (1.14–5.50) | 0.02 | 2.10 (0.87–5.08) | 0.10 |
| Statin treatment | 2.42 (1.15–5.09) | 0.02 | 1.72 (0.69–4.33) | 0.25 |
| Anti-hypertensive treatment | 1.68 (0.93–3.03) | 0.09 | 1.17 (0.59–2.34) | 0.66 |
| IHD | 1.66 (0.68–4.05) | 0.27 | Not tested | |
| Anti-depressive treatment | 0.61 (0.13–2.94) | 0.54 | Not tested | |
| Smoking | 0.46 (0.22–0.99) | 0.04 | 0.87 (0.37–2.07) | 0.76 |
| Platelet count | 0.99 (0.988–0.998) | 0.01 | 0.99 (0.986–0.997) | 0.01 |
| Hct | 0.84 (0.77–0.92) | <0.01 | 0.87 (0.79–0.96) | 0.01 |
OR, odds ratio; CI, confidence interval; PPI, proton pump inhibitor; IHD, ischaemic heart disease; Hct, haematocrit. Significant p-values (<0.05) are highlighted in bold.