Table 3.
Independent samples t-test (top) or linear regression (bottom) on effects of different variables on the platelet reaction unit value measured using the whole-blood VerifyNow P2Y12 assay.
| PRU mean ± SD | Mean difference (95% CI) | p-value | |
|---|---|---|---|
| Sex | |||
| Male | 161 ± 71 | ||
| Female | 164 ± 75 | −3.48 (−23.2; 16.3) | 0.73 |
| Current smoking | |||
| Smokers | 143 ± 67 | ||
| Non-smokers | 169 ± 74 | 25.0 (3.8; 48.2) | 0.02 |
| Diabetes mellitus | |||
| Diabetic | 198 ± 65 | ||
| Not diabetic | 158 ± 73 | −39.8 (−71.7; −7.9) | 0.02 |
| PPI-treatment | |||
| Yes | 177.1 ± 87 | ||
| No | 159 ± 70 | −15.6 (−51.8; 17.1) | 0.31 |
| Anti-hypertensive treatment | |||
| Yes | 165 ± 84 | ||
| No | 160.1 ± 64 | −4.4 (−25.1; 16.3) | 0.67 |
| Statin treatment | |||
| Yes | 173 ± 93 | ||
| No | 160 ± 69 | −13.4 (−46.7; 20.0) | 0.42 |
| Anti-depressive treatment | |||
| Yes | 137 ± 79 | ||
| No | 163 ± 72 | 26.6 (−19.8; 73.1) | 0.26 |
| IHD | |||
| Yes | 173 ± 76 | ||
| No | 162 ± 72 | −11.1 (−42.7; 20.4) | 0.49 |
| Previous stroke | |||
| Yes | 175 ± 89 | ||
| No | 161 ± 71 | −14.3 (−44.9; 16.2) | 0.36 |
| Beta (95% CI) | p-value | ||
| Age | 0.12 (−0.09; 1.46) | 0.08 | |
| Hgb | −0.32 (−36.2; −14.4) | <0.001 | |
| Platelet count | −0.19 (−0.38; −0.07) | 0.004 | |
| Hematocrit | −0.23 (−6.8; −1.9) | <0.001 | |
| Interval between ictus and blood sample collection (h) | −0.04 (−1.07; 0.54) | 0.52 | |
| Interval between clopidogrel administration (300-mg bolus) and blood sample collection (h) | −0.07 (−0.06; 0.02) | 0.28 | |
| Interval between blood sample collection and PRU analysis (min) | −0.02 (−0.16; 0.21) | 0.79 | |
PPI, proton pump inhibitor; IHD, ischaemic heart disease; Hgb, haemoglobin; SD, standard deviation. Significant p-values (<0.05) are highlighted in bold.