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. 2018 Aug 17;12:259. doi: 10.3389/fncel.2018.00259

Figure 1.

Figure 1

Gli3-deficiency induces brain malformation, which is rescued by depletion of miR-7. (A) The genetic modification in Emx1-Cre;Gli3fl/fl; miR-7-Sponge (EGS) mice model was induced by Emx1-Cre recombinase-dependent loss of floxed Exon8 in the Gli3 gene, and an expression of miR-7 sponge. (B–E) Cortical loss of Gli3 resulted in a notably larger and longer cortex, while the absence of miR-7 had the opposite effect of Gli3 at both P0 and P20. Values represent mean ± SEM. n > 9. ***P < 0.001. One-way ANOVA with post hoc test was used. Scale bar = 5 mm.