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Gli3-deficiency induces abnormal morphogenesis in the cortical midline. (A,B) Normal-developing brains displayed smooth cortical surface at the midline of cortices at P0 and P20. (C,D) Cortices losing Gli3 showed in-folding phenotype at the midline of cortices at P0, and the defect is maintained at P20. (E,F) Conditionally blocking the function of miR-7 from the cerebral cortex corrected the mis-folding defect in the midline in the Gli3-deficient brain.
