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. 2018 Aug 17;12:259. doi: 10.3389/fncel.2018.00259

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Copyright © 2018 Zhang, Mubarak, Chen, Lee, Pollock and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory role of Gli3 and miR-7 in modulating neuronal migration in the P0 cortex. (A–C) Absence of Gli3 facilitated more Tbr1⁺ and Satb2⁺ marked neurons to migrate into the upper bins in the midline region, while double-lose of miR-7 and Gli3 partially corrected the migratory process. (D–F) Subtle alteration of migratory process was detected in the upper bins in the cortical lateral region in EG and EGS brains. The markers Tbr1, Satb2 and DAPI stained for deeper bin newborn neurons, upper-bin newborn neurons and all cells, respectively. Values represent mean ± SEM. n > 9. ***P < 0.001; ns, not significant. One-way ANOVA with post hoc test was used. Scale bar = 100 μm.