Table 3.

Differences in side effect profiles across symptom categories.

Outcome = side effect type
	Positive	Negative	Context-specific
	Any
Constant (opioid mean)	0.966∗∗∗	0.496∗∗∗	0.695∗∗∗
	(0.942 to 0.989)	(0.428 to 0.565)	(0.637 to 0.753)
Anxiety symptoms	0.001	0.013	-0.006
	(-0.012 to 0.015)	(-0.033 to 0.059)	(-0.049 to 0.037)
Depression symptoms	-0.006	0.066∗∗	0.042∗
	(-0.029 to 0.017)	(0.002 to 0.131)	(-0.005 to 0.090)
Starting symptom level	-0.003∗	0.015∗∗∗	0.010∗∗
	(-0.007 to 0.000)	(0.007 to 0.024)	(0.002 to 0.019)
	Number
Constant (opioid mean)	4.583∗∗∗	1.081∗∗∗	1.652∗∗∗
	(4.013 to 5.154)	(0.768 to 1.395)	(1.356 to 1.947)
Anxiety symptoms	0.182	0.077	0.077
	(-0.100 to 0.465)	(-0.104 to 0.257)	(-0.113 to 0.268)
Depression symptoms	0.476∗	0.324∗∗	0.134
	(-0.010 to 0.962)	(0.053 to 0.596)	(-0.187 to 0.454)
Starting symptom level	-0.035	0.036∗∗	0.044∗∗
	(-0.142 to 0.072)	(0.000 to 0.072)	(0.003 to 0.085)
	Percent of possible
Constant (opioid mean)	0.241∗∗∗	0.083∗∗∗	0.165∗∗∗
	(0.211 to 0.271)	(0.059 to 0.107)	(0.136 to 0.195)
Anxiety symptoms	0.01	0.006	0.008
	(-0.005 to 0.024)	(-0.008 to 0.020)	(-0.011 to 0.027)
Depression symptoms	0.025∗	0.025∗∗	0.013
	(-0.001 to 0.051)	(0.004 to 0.046)	(-0.019 to 0.045)
Starting symptom level	-0.002	0.003∗∗	0.004∗∗
	(-0.007 to 0.004)	(0.000 to 0.006)	(0.000 to 0.009)

The first panel uses {0,1} outcomes for the presence of side effects in each category, the second uses the count of side effects reported by category, and the third uses the number of reported side effects for each category divided by the total number of possible side effects a user could select in that category. Robust standard errors are clustered at the user level. Coefficients are reported with 95% Confidence Intervals below. ^∗∗∗p < 0.01, ^∗∗p < 0.05, ^∗p < 0.10.