Table 2.

Conditional Knockout and Reporter Mouse Models

Mouse model	Mouse line	Description (what was the line used for?)	Reference
Reporter	ScxGFP	Allowed the identification of Scx-expression sites and the study of tendon/ligament lineage.	[95]
Reporter	ScxAP	Reporter line facilitates the identification of tendon cells and phenotypic analysis in a wide range of genetic backgrounds	[95]
Conditional	ScxCre-L ScxCre-H	Transgenic mouse lines were used for targeting genes specifically in the Scx-expressing domain.	[66]
Conditional	ScxCre/Cre KI	Mouse line was used to identify that Scleraxis is transiently needed for proper tissue maturation and integration of musculoskeletal components.	[148]
Reporter	Col1a1GFP	Reporter mice were used for the identification of a cell subpopulation at different stages of skeletogenesis.	[149,150]
Conditional	Col5a1flox/flox	Mice strain was crossed with ScxCre transgenic mice for the generation of a tendon and ligament-specific collagen V-null mice.	[151]
Reporter	Nes-GFP	GFP expression was used to isolate a subpopulation of nestin+ TSPCs. After single-cell analysis, gene expression profiles revealed that nestin expression was activated at specific stages of tendon development. Isolated nestin+ TSPCs showed superior tenogenic capacity.	[152]
Conditional	Dcnflox/flox/Bgnflox/flox	Used to study the role of both proteoglycans in mature tendons. Tendons showed alterations in collagen fibril structure, realignment, and mechanical properties.	[153]