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. 2018 Jun 14;27(18):3218–3232. doi: 10.1093/hmg/ddy225

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Altered morphology at the ultrastructural level in Gfpt1^tm1d^/^tm1d mouse muscle. Representative electron micrographs from 3 months old control and Gfpt1^tm1d^/^tm1d intercostal muscles. Examples of control (A), and Gfpt1^tm1d^/^tm1d(B–D) NMJs. Tubular aggregates (E) and subsarcolemmal vesicular structures (F–H) in Gfpt1^tm1d/tm1d mouse muscle. Synaptic vesicles (*), junctional folds (red arrow), mitochondria (M), tubular aggregates (TA), subsarcolemmal vesicular structures (white arrow), dense filamentous-like material (blue arrowhead) (n = 4).