Table 6.
Up- and downregulated genes, involved in “PI3K/Akt/mTOR pathway”.
| Gene | Name | CTR | MOR+CBD | Log2-Fold Change | Q Value |
|---|---|---|---|---|---|
| BCL2A1 | BCL2 related protein A1 | 0.0001 | 2.73565 | 14.73959 | 0.000108528 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 4.69263 | 106.74 | 4.50757 | 0.000108528 |
| CDK1 | cyclin dependent kinase 1 | 1.60127 | 9.99442 | 2.64191 | 0.000108528 |
| CCND1 | cyclin D1 | 57.5334 | 289.455 | 2.33087 | 0.000108528 |
| BCL2L1 | BCL2 like 1 | 2.45308 | 9.41279 | 1.94003 | 0.000108528 |
| MYC | MYC proto-oncogene, bHLH transcription factor | 5.20354 | 19.3543 | 1.89509 | 0.000108528 |
| RHEB | Ras homolog, mTORC1 binding | 15.1136 | 46.575 | 1.62371 | 0.000108528 |
| BRCA1 | BRCA1, DNA repair associated | 1.39172 | 3.87502 | 1.47734 | 0.000108528 |
| GYS1 | glycogen synthase 1 | 20.1343 | 40.8951 | 1.02227 | 0.000108528 |
| CRTC2 | CREB regulated transcription coactivator 2 | 7.74262 | 14.2376 | 0.87881 | 0.000108528 |
| AKT1S1 | AKT1 substrate 1 | 5.66925 | 9.57204 | 0.755668 | 0.00262175 |
| TSC1 | TSC complex subunit 1 | 7.62739 | 12.8277 | 0.75 | 0.000108528 |
| MAPK1 | mitogen-activated protein kinase 1 | 37.1635 | 61.9931 | 0.73822 | 0.000108528 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 14.858 | 24.2207 | 0.705002 | 0.00318817 |
| RPS6KB2 | ribosomal protein S6 kinase B2 | 10.6792 | 16.799 | 0.65357 | 0.00129168 |
| CREB3 | cAMP responsive element binding protein 3 | 15.8771 | 24.3326 | 0.615947 | 0.000108528 |
| EIF4E | eukaryotic translation initiation factor 4E | 13.0091 | 17.7561 | 0.448797 | 0.000108528 |
| NFKBIA | NFKB inhibitor alpha | 30.3404 | 38.8837 | 0.357928 | 0.00254092 |
| GSK3B | glycogen synthase kinase 3 beta | 7.29297 | 9.04263 | 0.310236 | 0.00350034 |
| PRKAA1 | protein kinase AMP-activated catalytic subunit alpha 1 | 10.8385 | 12.9494 | 0.256722 | 0.0156024 |
| GSK3A | glycogen synthase kinase 3 alpha | 24.6326 | 29.3496 | 0.252774 | 0.0231286 |
| MTOR | mechanistic target of rapamycin kinase | 10.8825 | 12.325 | 0.179576 | 0.0270992 |
| RPS6 | ribosomal protein S6 | 759.592 | 800.781 | 0.0761832 | 0.0354641 |
| MCL1 | MCL1, BCL2 family apoptosis regulator | 15.5899 | 13.3424 | −0.224596 | 0.0365845 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 18.1853 | 14.3317 | −0.343559 | 0.00374229 |
| EIF4B | eukaryotic translation initiation factor 4B | 108.227 | 84.7943 | −0.352014 | 0.000108528 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | 17.6961 | 12.3847 | −0.514879 | 0.000108528 |
| TSC2 | TSC complex subunit 2 | 37.2339 | 25.8014 | −0.529167 | 0.000108528 |
| PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | 3.9361 | 2.71759 | −0.534435 | 0.00600177 |
| RPS6KB1 | ribosomal protein S6 kinase B1 | 7.68103 | 5.28824 | −0.538514 | 0.000306871 |
| IKBKB | inhibitor of nuclear factor kappa B kinase subunit beta | 9.88765 | 6.66404 | −0.569232 | 0.000108528 |
| NFKB1 | nuclear factor kappa B subunit 1 | 9.63897 | 6.14856 | −0.64863 | 0.000108528 |
| RBL2 | RB transcriptional corepressor like 2 | 12.9876 | 7.44702 | −0.802397 | 0.000108528 |
| MAP2K7 | mitogen-activated protein kinase kinase 7 | 4.97253 | 2.44847 | −1.0221 | 0.000402551 |
| TP53 | tumor protein p53 | 21.8171 | 8.8547 | −1.30095 | 0.000108528 |
| PCK2 | phosphoenolpyruvate carboxykinase 2, mitochondrial | 10.9312 | 4.17877 | −1.38731 | 0.000108528 |
| CASP9 | Caspase 9 | 3.91636 | 1.29947 | −1.59159 | 0.000209655 |
| PTEN | phosphatase and tensin homolog | 50.3299 | 15.3705 | −1.71126 | 0.000108528 |
In table, we have reported: the nomenclature, the whole name, the gene expression values in untreated (CTR) or treated cells (MOR+CBD), Log2-fold change values, and q values (FDR) < 0.05.