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β-adrenoceptors mediate melatonin synthesis in RAW 264.7 macrophages. Propranolol (Prop.; 30 min) inhibits P-AANAT expression (A) and melatonin synthesis (B) induced by adrenaline (Adr; 0.2 nM; squares) and noradrenaline (Nor; 0.4 nM; circles). V = vehicle (0.001% ethanol). Data represent mean ± SEM (A)—each point is the mean of three to six independent experiments; (B)—the number of experiments is shown inside the bars).
