Table 3.
Top 20 KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways from enrichment analysis of SHH MB CSC transcriptome. The entire table is reported in Table S4.
| #Pathway ID | Pathway Description | Observed Gene Count | False Discovery Rate |
|---|---|---|---|
| 1100 | Metabolic pathways | 216 | 1.90 × 10−27 |
| 5016 | Huntington’s disease | 92 | 2.54 × 10−51 |
| 3010 | Ribosome | 91 | 3.04 × 10−69 |
| 190 | Oxidative phosphorylation | 83 | 6.82 × 10−56 |
| 5012 | Parkinson’s disease | 81 | 6.49 × 10−50 |
| 5010 | Alzheimer’s disease | 79 | 9.89 × 10−41 |
| 4932 | Non-alcoholic fatty liver disease (NAFLD) | 65 | 2.16 × 10−30 |
| 4141 | Protein processing in endoplasmic reticulum | 64 | 2.92 × 10−26 |
| 3040 | Spliceosome | 63 | 9.69 × 10−34 |
| 5169 | Epstein–Barr virus infection | 54 | 2.04 × 10−14 |
| 3013 | RNA transport | 52 | 1.98 × 10−17 |
| 4151 | PI3K-Akt signaling pathway | 48 | 7.44 × 10−4 |
| 1120 | Microbial metabolism in diverse environments | 47 | 5.73 × 10−13 |
| 5200 | Pathways in cancer | 46 | 5.82 × 10−4 |
| 1200 | Carbon metabolism | 44 | 2.69 × 10−19 |
| 4110 | Cell cycle | 44 | 6.66 × 10−17 |
| 4120 | Ubiquitin mediated proteolysis | 40 | 4.50 × 10−12 |
| 5203 | Viral carcinogenesis | 40 | 6.48 × 10−7 |
| 4810 | Regulation of actin cytoskeleton | 40 | 5.49 × 10−6 |
| 5205 | Proteoglycans in cancer | 40 | 1.07 × 10−5 |