Figure 1.

This figure identifies the primary location of sirtuins 1–7 in eukaryotes. Sirtuins are NAD+-dependent deacetylates which account for post-translational modifications of molecules within cells; sirtuins have a wide variety of functions including the promotion of longevity and the prevention in age-related diseases. For the purposes of the current report, specific interest is directed to mitochondrial SIRT3, the activity of which has been shown to be modulated by melatonin. SIRT3 is primarily located in the mitochondria where it co-localizes with melatonin. Both these molecules are involved in redox regulation and, as shown in this report, they are functionally intertwined. Single arrowheads identify structure; double headed arrows identify movement of molecules.