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. 2018 Aug 18;19(8):2439. doi: 10.3390/ijms19082439

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A summary of the proposed mechanisms by which melatonin preserves myocardial cell function after ischemia/reperfusion injury in type 1 diabetic rats. The involvement of AMPK→pAMPK was shown using compound C, a specific blocker of AMPK-signaling. The role of SIRT3 was documented with the use of SIRT3 siRNA. Melatonin protects against myocardial damage due to ischemia/reperfusion as indicated. Figure drawn from the findings of Yu et al. [216]. Red arrows indicate stimulation; blue arrows indicate inhibition; green arrows indicate flow of information.