Table 3.
Biochemical parameters in normal and overweight/obese PCOS women
|
Normal
(n=27) |
Overweight-obese
(n=85) |
P-value * | |
|---|---|---|---|
| Mean±SD | Mean±SD | ||
| FSH (mIU/ml) | 6.72 ± 2.03 | 6.52 ± 1.72 | 0.62 |
| LH (mIU/ml) | 8.69 ± 3.96 | 8.3 ± 4.28 | 0.65 |
| LH/FSH ratio | 1.29 ± 0.49 | 1.29 ± 0.8 | 0.99 |
| Free-testosterone (pg/ml) | 2.85 ± 1.47 | 2.79 ± 1.06 | 0.78 |
| Testosterone (ng/ml) | 1.08 ± 1.67 | 0.9 ± 1.13 | 0.54 |
| 17-OH-progesterone (ng/ml) | 1.31 ± 1.79 | 1.14 ± 0.91 | 0.587 |
| DHEAS (µg/dl)) | 179.09 ± 86.36 | 172.7 ± 73.64 | 0.71 |
| SHBG (nmol/L) | 45.24 ± 29.6 | 29.19 ± 13.31 | 0.01 |
| TSH (mIU/ml) | 2.18 ± 1.24 | 2.3 ± 1.17 | 0.67 |
| Prolactin (mlU/L) | 374.74± 185.8 | 265.11± 152.79 | 0.02 |
| Fasting insulin (µU/ml) | 10.87 ± 6.99 | 16.78 ± 7.41 | <0.001 |
| Fasting glucose (mg/dl) | 87.87 ± 9.27 | 89.01 ± 11.04 | 0.6 |
| Triglyceride (mg/dl) | 98.37 ± 27.46 | 139.4 ± 64.15 | 0.03 |
| Total cholesterol (mg/dl) | 175.77 ± 39 | 184.08 ± 37.49 | 0.33 |
| LDL-cholesterol (mg/dl) | 91.52 ± 8.92 | 104.52± 23.71 | 0.02 |
| HDL-cholesterol (mg/dl) | 58.27 ± 8.78 | 53.71± 12.84 | 0.01 |
| QUICKI < 0.34 | 0.37±0.03 | 0.31±0.01 | <0.001 |
| HOMA (IR) ≥ 3.15 | 2.01± 0.38 | 5.15 ± 1.93 | <0.001 |
Overweight (body mass index [BMI] ≥25 kg/m2
HOMA-IR: Insulin resistance calculated using HOMA model
QUICKI: Insulin sensitivity calculated using QUICKI model
*
t-Test.