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. 2018 Aug 10;19(8):2353. doi: 10.3390/ijms19082353

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Murine early hematopoiesis from long-term hematopoietic stem cells towards the different lineages. Plain and dashed arrows show the main and the alternative branch points, respectively. Hematopoietic progenitors do not express markers of the different hematopoietic lineages and are therefore said to be lineage-negative (Lin⁻). Markers used to characterize the different hematopoietic progenitors are indicated. LT-HSC: long-term hematopoietic stem cell (HSC); ST-HSC: short-term HSC; MPP: multipotent progenitor; LMPP: lymphoid-biased multipotent progenitor; MEP: megakaryocyte-erythroid progenitor; GMP: granulocyte-monocyte progenitor; CLP: common lymphoid progenitor; Mega: megakaryocyte; Erythro: erythrocyte; Granulo: granulocyte; Mono: monocyte; Lympho: lymphocyte; Lin: lineage markers.