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. 2018 Jul 30;19(8):2223. doi: 10.3390/ijms19082223

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Phosphomimetic mutant Kv7.5S53D has negatively shifted voltage-dependence of activation and is insensitive to forskolin/IBMX. (A) I–V relationships of Kv7.5 S53D current recorded before (filled circles, n = 4) and after (open circles, n = 4) application of forskolin (10 µM) in combination with IBMX (500 µM) for 5 min. (B) Mean fractional conductance plots calculated from tail currents measured in control (filled circles) and in the presence of forskolin/IBMX (open circles), fitted to a Boltzmann distribution (V_0.5 = −56.8 ± 5.3 mV in the absence and −58.4 ± 5.9 mV in the presence of forskolin/IBMX, n = 4); mean fractional conductance plots of wild-type Kv7.5 channels are shown in a gray solid line for control and gray dashed line in the presence of forskolin/IBMX.