Table 1.

Structure of ring-substituted (2E)-N-aryl-3-phenylprop-2-enamides 1–16, experimentally determined values of lipophilicity log k, calculated values of log P/Clog P, and electronic Hammett’s σ parameters.

Comp.	R	log k	Clog P a	log P b	σAr b
1	H	0.1146	3.6640	3.18	0.60
2	3-CH3	0.2729	4.1630	3.40	0.48
3	4-CH3	0.2640	4.1630	3.40	0.46
4	2-F	0.1330	3.4646	3.17	1.02
5	3-F	0.2327	4.0646	3.32	0.82
6	3-CF3	0.4859	4.9978	4.26	0.89
7	2,5-CH3	0.2691	4.0120	3.57	0.59
8	2,5-Cl	0.5799	4.5878	4.65	1.22
9	2,6-Cl	0.0632	3.7378	4.56	1.33
10	3,4-Cl	0.6821	5.3178	4.70	1.19
11	3,5-Cl	0.8155	5.4378	4.79	1.11
12	2,6-Br	0.0992	3.9778	4.80	1.33
13	3,5-CF3	0.9814	6.0386	5.68	1.05
14	2-F-5-Br	0.4875	4.4178	4.07	1.28
15	2-Br-5-F	0.4588	4.1378	4.12	1.19
16	2-Cl-5-CF3	0.6178	4.9509	4.88	1.19

^a calculated using ChemBioDraw Ultra 13.0; ^bcalculated using ACD/Percepta ver. 2012.