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. 2018 Jul 30;15(8):1614. doi: 10.3390/ijerph15081614

Figure 5.

Figure 5

E2, BPA, and OP effects and estrogen and progesterone receptor expressions in maternal uterus and implantation sites. The expression levels of ERα, PRα, and PRβ genes were measured by real-time PCR and normalized to that of 18S ribosomal RNA (RN18S). In uterus, (a) mRNA levels of ER were not changed by BPA or OP with/without ICI; (b) mRNA levels of PR were significantly low in all groups; (c) mRNA levels of PR-B were markedly low in all groups; In implantation sites, (d–f) the expressions of ERα mRNA were significantly decreased by OP. Statistical significance was determined by two-way ANOVA. * p < 0.05 vs. VE, ** p < 0.01 vs. VE, *** p < 0.001 vs. VE, # p < 0.05 EDs + ICI vs. EDs, ## p < 0.01 EDs + ICI vs. EDs, ### p < 0.001 EDs + ICI vs. EDs, & p < 0.05 vs. ICI, && p < 0.01 vs. ICI, &&& p < 0.001 vs. ICI. n = 5 mice per group for uterus, n = 3 mice per group for implantation sites. Treatments: E2; 40 µg/kg/day, BPA; 100 mg/kg, OP; 100 mg/kg, ICI; 4 mg/kg.