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. 2018 Aug 18;19(8):2437. doi: 10.3390/ijms19082437

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of TEA on Kv2.1 and TASK-3 channels expressed in HEK-293 cells. (A) Rat Kv2.1 channel currents measured with a voltage protocol (400-ms steps from −100 mV to 100 mV with an increment of 10 mV and a holding potential of −80 mV) before (left) and after (right) the exposition to 100 mM of TEA. (B) Application of 100 mM of TEA on TASK-3 channels, before (left) and after (right) the treatment. (C) Dose-response relationship of TEA on Kv2.1 and TASK-3 channel. TEA blockade was analyzed at +80 mV test pulse. Kv2.1 IC₅₀ value was 16.9 ± 1.7 mM (n = 4).