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Schematic representation of the TASK-3 channel construct. A representation of the TASK-3 WT channel topological model is shown at the left. In this representation, each subunit has two pore-forming domains (P loops) and four transmembrane domains (denoted M1-M4). To the right is shown the TASK-3/2Loop2 channel construct with the amino acid sequence of selectivity filter illustrated in boxes.
