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. 2018 Aug 18;19(8):2437. doi: 10.3390/ijms19082437

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Functional evaluation of TASK-3/2Loop2 construct: effect on rectification, time-dependence and selectivity. Representative whole-cell recordings of TASK-3 (A,B, n = 6) and TASK-3/2Loop2 (D,E, n = 6) K⁺-mediated currents recorded according to the voltage protocol described in the legend of Figure 1. The results in (A–C) correspond to TASK-3 WT channels and those in (D–F) to TASK-3/2loop2 construct. In (A,D), the extracellular medium was 135 mM Na⁺ and 5 mM K⁺. In (B,E), the extracellular Na⁺ was replaced by an equimolar amount of K⁺(140 mM). (C,F) shows the representative current-voltage relations for TASK-3 and 2loop2 channels under different extracellular K⁺ concentrations (closed circles 5 mM; open circles 140 mM).