Figure 6.

Representative examples of the activation pattern of spontaneous bioelectrical activity in primary hippocampal cultures in the posthypoxic period: A—hypoxia, B—hypoxia+BDNF (1 ng/mL), C—hypoxia + AAV-Syn-BDNF-EGFP. The colour scale corresponds to the time of occurrence of the first spike in the network burst and is presented in squares according to the electrodes of the multielectrode array. The data show that hypoxia induced a decrease in the signal transmission speed in the network and significant changes in the activation pattern of the network burst. BDNF overexpression contributed to maintaining the activation pattern in the posthypoxic period.