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. 2018 Aug 4;19(8):2289. doi: 10.3390/ijms19082289

Figure 3.

Figure 3

The miR-130/301 family modulates the expression of factors genetically associated with PAH. Following transfection with the indicated miR-130a mimic (A–C), miR-130/301 inhibitor (tiny-130) (D–F), or related scrambled controls, transcript levels of factors genetically associated with PAH were analyzed by RT-qPCR in PAAFs, PAECs, and PASMCs. Underlined genes: Predicted targets of miR-130/301 members (TargetScan). Mean expression in control groups (si-NC) was assigned a fold change of 1, to which relevant samples were compared. Data are expressed as mean ± SD (* p < 0.05, ** p < 0.01, *** p < 0.001) of three independent experiments. Paired samples were compared using a 2-tailed Student’s t-test. (G) Schematic of the main results. Red: upregulated genes. Green: downregulated genes, upon miR-130a forced expression.