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PAR1 biased signaling is orchestrated by a diverse set of unique proteases, both noncanonical (MMP-1) and canonical (thrombin). PAR1 activation by MMP-1 and thrombin results in two different cleavage sites with the MMP-1 generated activating peptide (AP) PR-SFLLRN-NH2 and the thrombin generated SFLLRN-NH2. N-terminal cleavage sites are listed for MMP-13, Elastase, and APC. Tethered AP sequences are shown for Elastase and APC.
