Canonical	a thrombin mediated activation of PAR1
Noncanonical	protease that is distinct from thrombin that generates a unique tethered ligand sequence in PAR1
HMGA2	High-mobility group AT-hook2 nuclear protein-a member of the superfamily of non-histone chromatin family that regulate gene expression through remodeling of the chromatin
EMT	epithelial-mesenchymal transition
NF-κB	nuclear factor-kappaB
miR-17	microRNA
E-cadherin	type-1 transmembrane glycoprotein
Twist	basic helix-loop-helix transcription factor
Hippo pathway	kinase cascade especially important in development
TAZ	transcription regulator 1
Akt	protein kinase B
Vimentin	structural protein
PH	plekstrin homology
Etk	tyrosine kinase
ARRDC3	Arrestin domain containing 3β-arrestin protein
JNK	Jun-N-terminal kinase
ALEX1	a tumor-suppressor member of the armadillo family
Tpl2	tumor progression locus 2 kinase
Rac1	Rho GTPase
PLD	phospholipase D
RhoA,Rap1A	Ras related GTPases
ERK	the extracellular signal-regulated kinase
VEGF	vascular endothelial growth factor
CXCR1/2	C-X-C chemokine receptors 1 and 2
ROS	reactive oxygen species
MMP-1	matrix metalloproteinase 1
PAR1	protease activated receptor 1
Human MCF7-PAR1 (clone N55)	stable high PAR1 expressing MCF7 clone 55 (note MCF-7 cells don not express PAR1)
PAR1-null	lack of PAR1 expression
Human MCF7-PAR1 (R310E)	stable cell line expression PAR1 with an R310E mutation that results in high expression of a PAR1 non-signaling receptor
NCR nu/nu mice	immuno-deficient mouse model
MMP-1 Inh	FN439 matrix metalloprotease 1 inhibitor
vWF	von Willebrand Factor
Human MDA-MB-231	PAR1 expressing breast cancer cell line
PZ-128	also known as P1pal-7 is the PAR1 antagonist pepducin
metastatic incidence	appearance of macroscopic tumor nodules at the surface of lung or using histologic analysis of lung sections
tumor incidence	number of tumors formed after subcutaneous implantation into mammary fat pads
TUNEL	terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling
A549	human PAR1 expressing lung adenocarcinoma
LLC1	mouse Lewis lung carcinoma
LLC1-shPAR1	a short hairpin-RNA that silenced PAR1 expression
LLC1-shControl	control (shLuciferase)
MMP1a-KO	MMP1 knockout mouse
OVCAR-4 and SKOV-3	Human ovarian cell lines
Ascites formation	production of large volume of fluid in the peritoneal cavity
Intraperitoneal cavity	space between the abdominal wall and the surrounding interanal organs
Peritoneal carcinomatosis	mice were injected into the peritoneal cavity with ovarian cancer cells
FAK ERK1/2	focal adhesion kinase extracellular signal-regulated kinase 1 and 2