Table 4.
Meta-prediction: Death from air pollution on MTHFR 677 genotypes for controls and congenital heart diseases (CHD) cases, and CHD risks for children (35 studies).
| Partition Tree | Tukey Test | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Variable | AICc | AP Death | Count | Mean | SD | Levels Compared | D | SED | Lower CI | Upper CI | p |
| TT % ct | 237.40 | 2, 3 | 16 | 9.58 | 8.58 | 4/2 | 5.42 | 4.69 | −6.13 | 16.97 | 0.49 |
| 4 | 18 | 14.45 | 6.19 | 4/3 | 4.75 | 2.74 | −1.99 | 11.49 | 0.21 | ||
| 3/2 | 0.67 | 4.82 | −11.2 | 12.53 | 0.99 | ||||||
| TT % CHD | 271.23 | 2, 3 | 16 | 13.95 | 12.54 | 4/2 | 10.86 | 7.69 | −8.06 | 29.78 | 0.35 |
| 4 | 18 | 21.57 | 11.86 | 4/3 | 6.87 | 4.49 | −4.17 | 17.91 | 0.29 | ||
| 3/2 | 3.99 | 7.89 | −15.44 | 23.42 | 0.87 | ||||||
| CT % ct | 271.28 | 3, 2 | 16 | 35.16 | 16.10 | 4/3 | 12.36 | 4.47 | 1.36 | 23.37 | 0.03 |
| 4 | 18 | 46.51 | 7.14 | 4/2 | 6.91 | 7.66 | −11.94 | 25.76 | 0.64 | ||
| 2/3 | 5.45 | 7.87 | −13.91 | 24.82 | 0.77 | ||||||
| CT % CHD | 271.16 | 2, 3 | 16 | 39.00 | 15.60 | 4/2 | 10.26 | 7.67 | −8.61 | 29.13 | 0.39 |
| 4 | 18 | 45.42 | 8.00 | 4/3 | 5.54 | 4.47 | −5.47 | 16.56 | 0.44 | ||
| 3/2 | 4.72 | 7.87 | −14.66 | 24.10 | 0.82 | ||||||
| TT + CT % ct | 289.28 | 2, 3 | 16 | 44.72 | 20.19 | 4/3 | 17.14 | 5.85 | 2.73 | 31.55 | 0.02 |
| 4 | 18 | 60.96 | 10.74 | 4/2 | 12.33 | 10.03 | −12.36 | 37.02 | 0.45 | ||
| 2/3 | 4.81 | 10.30 | −20.55 | 30.16 | 0.89 | ||||||
| TT + CT % | 300.01 | 2, 3 | 16 | 52.94 | 21.86 | 4/2 | 21.11 | 11.69 | −7.66 | 49.88 | 0.18 |
| CHD | 4 | 18 | 66.99 | 15.16 | 4/3 | 12.42 | 6.82 | −4.37 | 29.21 | 0.18 | |
| 3/2 | 8.69 | 12.01 | −20.86 | 38.23 | 0.75 | ||||||
| RR TT | 56.12 | 2, 3 | 13 | 1.30 | 0.46 | 4/2 | 0.24 | 0.42 | −0.80 | 1.28 | 0.84 |
| 4 | 18 | 1.50 | 0.61 | 4/3 | 0.20 | 0.22 | −0.33 | 0.73 | 0.63 | ||
| 3/2 | 0.04 | 0.43 | −1.03 | 1.11 | 0.996 | ||||||
| RR CT | 62.47 | 2, 3 | 16 | 1.23 | 0.81 | 3/2 | 0.68 | 0.35 | −0.18 | 1.54 | 0.14 |
| 4 | 18 | 0.98 | 0.15 | 3/4 | 0.37 | 0.20 | −0.11 | 0.86 | 0.16 | ||
| 4/2 | 0.31 | 0.34 | −0.53 | 1.14 | 0.64 | ||||||
| RR TT + CT | 57.95 | 2, 3 | 16 | 1.29 | 0.76 | 3/2 | 0.74 | 0.32 | −0.05 | 1.52 | 0.07 |
| 4 | 18 | 1.10 | 0.15 | 4/2 | 0.40 | 0.31 | −0.36 | 1.17 | 0.41 | ||
| 3/4 | 0.33 | 0.18 | −0.11 | 0.78 | 0.18 | ||||||
Note. RR: risk ratio; AP death: Death rates from air pollution, levels per million: 2: <100 (India, Mexico, and Brazil), 3: 100–250 (Germany, US, Iran, Egypt), 4: >250 (Portugal, Netherlands, China, Taiwan, Turkey); ct: control group; D: Difference; SED: SE Difference; AP death was split by partitioning the original group into pairs of subgroups with reference to the dependent variable (e.g., the percentage of polymorphism and CHD risks) by recursive partition trees in the JMP 13 program (SAS Institute).