Table 2.

Values of the parameters α and β and their ratio for radiotherapy alone and in combination with the different sensitizing agents.

Cell Line	Sensitizing Agent	α (Gy−1)	β (Gy−2)	α-EF *	β-EF *
SiHa	RT	0.21 ± 0.04	0.05 ± 0.01	1.00 ± 0.00	1.00 ± 0.21
SiHa	RT + HT42	0.32 ± 0.07	0.07 ± 0.01	1.56 ± 0.45	1.38 ± 0.28
SiHa	RT + PARP1-i	0.51 ± 0.05	0.02 ± 0.01	2.46 ± 0.51	0.45 ± 0.24
SiHa	RT + HSP-i	0.22 ± 0.02	0.03 ± 0.00	1.07 ± 0.21	0.62 ± 0.13
SiHa	RT + DNA-PKcs-i	1.00 ± 0.11	0.02 ± 0.03	4.85 ± 1.02	0.43 ± 0.64
SiHa	RT + HT + PARP1-i	0.84 ± 0.12 **	0.01 ± 0.03	4.06 ± 0.94 **	0.25 ± 0.68
SiHa	RT + HT + HSP-i	0.23 ± 0.03	0.06 ± 0.01 ***	1.12 ± 0.24	1.21 ± 0.22 ***
SiHa	RT + HT + DNA-PKcs-i	1.60 ± 0.02 **	0.07 ± 0.02	7.77 ± 1.40 **	1.49 ± 0.48
HeLa	RT	0.30 ± 0.04	0.04 ± 0.01	1.00 ± 0.18	1.00 ± 0.00
HeLa	RT + HT42	0.38 ± 0.04	0.06 ± 0.01	1.27 ± 0.21	1.53 ± 0.39
HeLa	RT + PARP1-i	0.56 ± 0.04	0.03 ± 0.01	1.88 ± 0.27	0.75 ± 0.27
HeLa	RT + HSP-i	0.26 ± 0.02	0.02 ± 0.00	0.87 ± 0.12	0.44 ± 0.14
HeLa	RT + DNA-PKcs-i	0.41 ± 0.07	0.06 ± 0.01	1.37 ± 0.29	1.67 ± 0.43
HeLa	RT + HT + PARP1-i	1.03 ± 0.09 **	0.04 ± 0.02	3.46 ± 0.53 **	1.14 ± 0.60
HeLa	RT + HT + HSP-i	0.41 ± 0.04 ***	0.07 ± 0.01 ***	1.37 ± 0.22 ***	1.97 ± 0.49 ***
HeLa	RT + HT + DNA-PKcs-i	0.87 ± 0.06 **	0.02 ± 0.01	2.91 ± 0.41 **	0.56 ± 0.30

* EF = Enhancement Factor; ** significantly different from both duo modality treatments; *** significantly different from RT + HSP-i.