Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 25;19(8):2176. doi: 10.3390/ijms19082176

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Localization of Tspo mRNA in healthy and diseased colon tissue. Tspo mRNA was localized in the cytoplasm of goblet (G) and absorptive cells of the Crypts of Lieberkhün and plasma cells (P) located in the lamina propria, and in the nuclei and cytoplasm of lymphocytes (L) located in the lamina propria of normal colon tissue (A,B). Localization of the Tspo mRNA was found in the cytoplasm of tumour cells that are mucin-secreting and arranged in adenomatous tubular glands (AG) and fibromuscular stroma (FM) of Grade I colonic adenocarcinoma (C,D). In Grade II colonic adenocarcinoma, Tspo mRNA was localized in the cytoplasm of tumour cells arranged as adenomatous glands (AG) or solid sheets (E,F). Tspo mRNA was localized in the cytoplasm of tumour cells that are predominantly arranged as a solid pattern of Grade III colonic adenocarcinoma (G,H). (I,J) Negative control for the subcellular localization of Tspo mRNA. Sense probes were used to probe tissue preparations and this was analysed colorimetrically and fluorescently. Tissues were magnified at 1000×.