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. 2018 Jul 25;19(8):2176. doi: 10.3390/ijms19082176

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Subcellular Localization of Tspo mRNA in healthy and diseased Liver Tissues: Localization in Normal Liver Tissue (A,B) where Tspo mRNA is expressed in the cytoplasm of hepatocytes (H) and in the nuclei and cytoplasm of Kupffer cells (K) and endothelial cells (E) of the sinusoids. A comparison of the fluorescent intensity between cancer (D,F) and healthy tissue (B) shows a decrease in the expression level of Tspo in cancer. Grade II hepatocellular carcinoma (C,D) express PBR mRNA in the cytoplasm of tumour cells having either a trabecular or pseudoglandular pattern while Grade III hepatocellular carcinoma (E,F) express PBR mRNA in the nuclei and cytoplasm of tumour cells that resemble anaplastic giant cells to spindle-shaped cells. (G,H) Negative control for the subcellular localization of Tspo mRNA. Sense probes were used to probe tissue preparations and this was analysed colorimetrically and fluorescently. Tissues were magnified at 1000×.