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. 2018 Aug 15;19(8):2405. doi: 10.3390/ijms19082405

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Paw edema induced by Cdtsp 2, and corresponding levels of cyclooxygenase 2 (COX-2) expression, and prostaglandin E2 (PGE2) and malondialdehyde (MDA) concentrations. (A) Volume of edema induced by Cdt serine protease. Plots (B–D) show the results for COX-2 expression, and for PGE2 and MDA concentrations, respectively. The results are expressed as means ± standard deviation (n = 5). Significant differences are marked with (*) (two-way ANOVA with Bonferroni as a posteriori test; F = 150.0 and p < 0.001).